AKK PROBIO is a probiotic product based on the Akkermansia muciniphila (AKK) bacteria, known as the “mucin-degrading” strain. It was selected from 200 AKK strains and is certified by the China General Microbiological Culture Collection Center (CGMCC No.20955). AKK PROBIO has shown significant potential in gut barrier protection, weight management, anti-aging, and anti-inflammatory effects across over 3,000 global studies.

Superior Stress Resistance: Maintains activity in pH 5.8–7.2 and low-oxygen environments; over 80% survival after 6 hours in simulated gastrointestinal fluids, solving the colonization challenge of traditional probiotics.

Functional Evolution: Possesses a 2.81 Mb genome with 2,309 coding genes, including a new FIAF activation cluster and amuX gene, which enhances mucin degradation by 40% and improves colonization.

Safety Standard: The first AKK strain recognized as GRAS (Generally Recognized as Safe) by the FDA. Both live and inactivated forms have passed toxicology and antibiotic resistance tests, with no pathogenic risk.

AKK bacteria regulate gut barrier function through outer membrane protein Amuc_1100 and short-chain fatty acids (SCFAs, e.g., acetate and propionate), promoting goblet cell differentiation and mucin secretion. They also stimulate GLP-1/2 secretion, improving glucose and lipid metabolism and insulin sensitivity, while suppressing pro-inflammatory factors such as IL-1β and IL-6 to enhance immune regulation.

To maintain the maximum activity and effectiveness, it is recommended to store AKK PROBIO capsules in the refrigerator. The bottles include desiccants to optimize stability and ensure the bacteria remain effective throughout the shelf life.