Diagram of AKK's Mechanisms for Regulating Intestinal Barrier, Metabolism, and Immunity
Mechanism of Action
AKK regulate intestinal barrier function by activating receptors like FFAR2/3 via outer membrane protein Amuc_1100 and short-chain fatty acids (acetate, propionate), promoting goblet cell differentiation and mucus secretion. They also enhance glucose-lipid metabolism and insulin sensitivity by stimulating GLP-1/2 secretion, while inhibiting pro-inflammatory factors (IL-1β, IL-6) to boost immune regulation.
Literature Source: Cani PD, Knauf C. A newly identified protein from Akkermansia muciniphila stimulates GLP-1 secretion. Cell Metab. 2021 Jun 1;33(6):1073-1075. doi: 10.1016/j.cmet.2021.05.004.
Akkermansia muciniphila: Comprehensive Guide
🌍 The Journey of a unique gut resident not all gut microbes are created equal. Among the trillions living inside us, Akkermansia muciniphila (AKK) stands out — a mucus-loving bacterium that strengthens the very barrier it feeds on. Scientists are discovering that AKK’s ability to colonize the gut depends on a delicate balance between biology, diet, and environment. Understanding this process sheds light on its role in metabolism, immunity, and even longevity... ...
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