What is Akkermansia muciniphila?
Akkermansia muciniphila, commonly known as AKK bacteria, was first isolated from the faeces of healthy adults by researchers at Wageningen University's microbiology laboratory in the Netherlands in 2004. It represents the first discovered member of the Firmicutes phylum and is a naturally occurring beneficial bacterium in the human gut, constituting only 3-5% of the intestinal microbiota. Due to its ability to thrive within the intestinal mucus layer, Akkermansia exhibits extensive synergistic effects, directly influencing multiple vital physiological functions including host immunity, metabolism, and inflammation.
Akkermansia muciniphila (AKK) is a naturally occurring gut bacterium found in the human intestinal mucosal layer that interacts with immune cells and supports gut barrier function. It has been studied for its potential role in metabolic health, immunity, and intestinal balance.
Clinical Study
Clinical research on AKK PROBIO® shows effects in overweight adults and gut microbiota modulation. A randomized controlled trial found improvement in metabolic parameters, body composition, and gut microbiota balance compared with placebo.
“The world's largest sample-sized study and the first dual clinical research on the brain-gut axis and live bacteria/postbiotics has been formally published in Food Science and Human Wellness. Following an eight-week intervention, both AKK PROBIO live bacteria and its postbiotics significantly improved patients' body weight, body fat mass, BMI, and waist-to-hip ratio (p<0.01).”
- Pasteurized Akkermansia muciniphila AKK PROBIO Attenuates Obesity Through Gut Microbiota-SCFA-GLP-1 Axis and Potential Involvement of AMPK/PPAR-α Pathway
16 domestic and international patents
We have established a comprehensive intellectual property portfolio centred on the AKK PROBIO strain, encompassing 16 domestic and international invention patents. Our research findings have been published in 11 SCI-indexed papers and one Chinese core journal article, with functional applications spanning multiple key areas including body contouring, immune modulation, and enhanced GLP-1 secretion.
Latest Studies & Scientific Publications
- Inactivated Akkermansia muciniphila AKKPROBIO Preserves Intestinal Homeostasis and Ameliorates DSS-Induced Colitis in Mice.
- The alleviating effect of Akkermansia muciniphila PROBIO on AOM/DSS-induced colorectal cancer in mice and its regulatory effect on gut microbiota.
- Pasteurized Akkermansia muciniphila AKK PROBIO Attenuates Obesity Through Gut Microbiota-SCFA-GLP-1 Axis and Potential Involvement of AMPK/PPAR-a Pathway.
- Akkermansia muciniphila PROBIO ameliorates overweight via gut microbiota modulation: a randomized controlled trial.
- Heat-inactivated Akkermansia muciniphila AKK-PROBIO ameliorates cyclophosphamide-induced immunosuppression via the NF-kB/MAPK pathway and gut microbiota modulation
- Akkermansia muciniphila PROBIO therapy promotes arginine biosynthesis and reverses reproductive impairments in polycystic ovary syndrome rats
- Immune restoration mechanism analysis of Akkermansia PROBIO in mice treated with cyclophosphamide through Re-balancing microbiota composition
- Supplementation of Akkermansia muciniphila improves diabetic kidney disease by regulating gut microbiome in db/db mice
- Research on preventive effect of Akkermansia muciniphila AKK PROBIO on acute gouty arthritis in mice
Research
Akkermansia coli demonstrates promising application potential in diabetes, obesity, anti-ageing, amyotrophic lateral sclerosis (ALS), inflammatory bowel disease (IBD), metabolic regulation, and immunotherapy. This review references over 150 AKK-related literature and clinical studies.
The gut-brain axis facilitates communication between the gut and brain, with gut microbiota influencing neural, immune, and endocrine systems through reciprocal interactions. AKK bacteria, as beneficial gut flora, modulate neural responses by producing short-chain fatty acids while directly or indirectly regulating the gut-brain axis via immune pathways. This includes ameliorating metabolic disorders, psychiatric conditions, and neurodegenerative diseases arising from dysbiosis.
Manufacturing
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