Featured human clinical trial
130-subject, 8-week randomized controlled trial
A 2025 randomized, double-blind, placebo-controlled trial in overweight adults reported that both live and pasteurized AKK PROBIO® were associated with statistically significant reductions in body weight, BMI, and body fat percentage over 8 weeks. The study also observed improvements in liver function markers, blood lipid profiles, emotional well-being scores, and gut microbiota composition.
View full textSafety research
Characterization and toxicology support
Published safety materials include strain characterization, preliminary safety evaluation, genotoxicity context, and subchronic toxicity evidence. These materials support technical, regulatory, and QA review.
View safety characterizationMechanism research
Gut barrier, SCFA, GLP-1, immune, uric acid, PCOS, and neuroinflammation models
Preclinical studies provide mechanism context across gut barrier integrity, metabolic health, immune modulation, uric acid metabolism, reproductive health, and neurological research. These studies help technical teams understand biological pathways and application fit.
Evidence is provided for B2B ingredient evaluation, not as finished-product disease claims.
Evidence materials
Study materials for R&D, regulatory, and QA review
AKK PROBIO® evidence materials bring together human clinical research, safety characterization, mechanism studies, and preclinical research in one technical review pathway.
Publication index
Strain-specific citation map
AKK PROBIO® strain-specific evidence includes 13 peer-reviewed publications, 7 clinical studies, and 18 strain-specific patents. The index below gives technical teams direct research anchors for evaluation.
Akkermansia muciniphila PROBIO ameliorates overweight via gut microbiota modulation: a randomized controlled trial
Food Science and Human Wellness, 2025. Human RCT, 130 subjects, 8-week, double-blind, placebo-controlled. DOI: 10.26599/FSHW.2025.9250659.
View full textInactivated Akkermansia muciniphila AKK PROBIO Preserves Intestinal Homeostasis and Ameliorates DSS-Induced Colitis in Mice
Foods, 2025. Animal study. PMID: 41376001. DOI: 10.3390/foods14234063.
View PubMed recordPasteurized Akkermansia muciniphila AKK PROBIO Attenuates Obesity Through Gut Microbiota-SCFA-GLP-1 Axis
Probiotics and Antimicrobial Proteins, 2026. Animal study. PMID: 41123834. DOI: 10.1007/s12602-025-10805-x.
View DOIHeat-inactivated Akkermansia muciniphila AKK-PROBIO ameliorates cyclophosphamide-induced immunosuppression
Anaerobe, 2026. Animal study. PMID: 41297661. DOI: 10.1016/j.anaerobe.2025.103016.
View DOICharacterization and Preliminary Safety Evaluation of Akkermansia muciniphila PROBIO
Foods, 2024. Characterization and safety evaluation. Full text available through PMC.
View full textAkkermansia muciniphila PROBIO therapy promotes arginine biosynthesis and reverses reproductive impairments in PCOS rats
Frontiers of Medicine, 2025. Animal study. DOI: 10.1007/s11684-025-1161-3.
View DOIResearch on preventive effect of Akkermansia muciniphila AKK PROBIO on acute gouty arthritis in mice
Food Science & Nutrition, 2024. Animal study. PMID: 39479687. DOI: 10.1002/fsn3.4367.
View PubMed recordLack of genotoxicity and subchronic toxicity in safety assessment studies of Akkermansia muciniphila formulation
Toxicology Reports, 2024. Species-level safety evidence. PMID: 39554606. DOI: 10.1016/j.toxrep.2024.101790.
View DOIAkkermansia muciniphila reduces neuroinflammation and Aβ deposition via tryptophan metabolism
Alzheimer's Research & Therapy, 2026. Animal study. PMID: 41715194. DOI: 10.1186/s13195-025-01880-x.
View PubMed recordIs there human clinical trial data for AKK PROBIO?
Yes. A 2025 randomized, double-blind, placebo-controlled trial enrolled 130 overweight adults and studied both live and pasteurized AKK PROBIO® over 8 weeks.
What health areas has AKK PROBIO been studied in?
Published research spans weight management, gut barrier integrity, metabolic health, immune modulation, uric acid metabolism, reproductive health, neuroinflammation, and safety/toxicology.
Request the complete clinical and technical dossier
Technical teams can request study summaries, citation references, safety materials, regulatory documents, and application-specific documentation.
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