RESEARCH ON AKK PROBIO
The strain number for AKK is CGMCC No. 20955, with quality traceability.
Previously published literature on AKK bacteria has compiled major research and clinical projects utilising this strain, demonstrating that maintaining its abundance correlates with obesity, diabetes, hepatic steatosis, inflammation (colitis), and response to cancer immunotherapy; Through gut-brain axis regulation, it modulates neurotransmitter synthesis and receptor expression, influencing mood, cognition, and circadian rhythms, demonstrating beneficial effects on amyotrophic lateral sclerosis, insomnia disorders, and depression/anxiety.
As a next-generation probiotic, AKK is a naturally occurring beneficial bacterium in the human body. Retaining within the outer mucosal layer without penetrating deeper layers, its colonisation at optimal abundance promotes natural renewal of the mucus barrier. Safety concerns are minimal, with virtually no adverse reactions reported.
Benefits of AKK PROBIO
Metabolic Health
Gut-barrier Support
Brain-Gut Axis
Immune Support
The short-chain fatty acids (SCFAs) produced by AKK bacteria, along with the metabolic enzyme membrane lipid a15:0-i15:0 PE and outer membrane protein Amuc_1100, suppress inflammation by efficiently degrading mucin-derived SCFAs. They regulate and enhance human immune function through both indirect and direct mechanisms.
The gut-brain axis facilitates communication between the gut and brain via interactions among the nervous, immune, and endocrine systems. AKK bacteria, as beneficial gut microbiota, regulate neural responses through SCFA production while directly or indirectly modulating the gut-brain axis by influencing immune pathways. This includes ameliorating metabolic disorders, psychiatric conditions, and neurodegenerative diseases arising from dysbiosis.
Metabolic balance & weight-related research
AKK PROBIO reduce the likelihood of abnormal immune system stimulation by maintaining microbial homeostasis and barrier integrity. By decreasing the translocation of microbe-associated molecules into the body, AKK helps alleviate persistent immune system activation, thereby lowering the underlying risk of chronic low-grade inflammation formation overall.
Intestinal barrier integrity
The integrity of the intestinal barrier is crucial for maintaining gut health and immune homeostasis.AKK bacteria enhance immunity by improving the host's intestinal barrier and gut microbiota homeostasis, thereby resisting and suppressing inflammation.
Microbiota signaling
&Nervous system
Emerging research highlights the role of gut microbiota in the gut–brain axis.Akkermansia muciniphila is being studied for its potential involvement in microbiota–brain communication through metabolic and immune pathways.
Immune Support
The gut microbiome plays an important role in immune regulation.Research suggests that Akkermansia muciniphila may be associated with immune system interactions through its role in maintaining gut environment balance.